A variant-proof COVID vaccine? The common cold can help scientists create a “holy grail”.

London – T cells produced as part of the body’s natural immune response to the common cold can help protect against serious illness. COVID-19According to a study by British researchers at Imperial College London, CBS News was told that the findings could help scientists develop a vaccine that would be more effective against new strains of the corona virus.


Of the study, Which was peer-reviewed and published in the journal Nature Communications, began in September 2020 and looked at 52 home contacts of people who had a positive test for COVID-19. It found that 26 people who were infected with the corona virus but did not become ill had significantly higher cross-reactivity. T cellsThe last common cold is caused by the common cold, compared to people who became infected with COVID.

Don’t trust it. “Exploit” it.

“It should not be concluded that if you have a common cold, you don’t have to worry about getting COVID-19,” Professor Aljit Lalwani, one of the study’s authors, told CBS News.


This is due to a number of reasons, not all colds are caused by the corona virus, and the ability of T cells to fight the symptomatic infection wears off over time.

“What the study tells us is that there is a mechanism, a natural mechanism of natural immunity, which is caused by the corona virus infection of the common cold. So it’s not a matter of relying on it. It’s about taking advantage of it and using it naturally. Creating a strong immune system to make a better vaccine. “


The majority of existing COVID-19 vaccines specifically target the virus’s spike protein, which it uses to attach to healthy human cells, Lalwani said. Vaccines cause the body to produce antibodies and T cells that respond to this protein. It provides good protection. Against the corona virus So far, but as seen. اومیکرونNumerous mutations in spike proteins can make vaccines less effective.

Lalwani says research at Imperial College has shown that other corona viruses (which are common) cause T cells produced after the common cold to attack a type of protein known as COVID-19. They stay the same in different situations. These endogenous proteins are responsible for replicating the virus instead of attaching to the outer cells. He explained that this important role in the evolution of the virus gives it very little ability to change.

“The fact is that (T cells) can attack the internal proteins of each of these related viruses. [COVID-19 variants] This means that they provide what is called a broad cross-protection, “Lalwani told CBS News. The goal is. And clearly, SARS-CoV-2 is under tremendous pressure in the global population because most people now have these antibodies, whether due to vaccination or infection, so the virus is trying naturally. That is, the immune system must be protected by mutation, which is why there are so many mutations in the Omicron Spike protein. But the internal proteins are relatively unchanged. “


Lalwani said the study should have an impact on how scientists approach the development of covid vaccines in the future.

“This is a sure green light to move forward and develop a T-cell inducing vaccine for the underlying core proteins, which will protect against current and future variations,” he said. “We are very fortunate that immunologists call it the ‘Holy Grill’, so we want people to understand that and to see that, finally, there is a way to deal with future variations.” “


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